Rhea Ipratropium + Salbutamol Side Effects

Many of the listed undesirable effects can be assigned to the anticholinergic and beta₂-sympathomimetic properties of ipratropium bromide + salbutamol. As with all inhalation therapy ipratropium bromide + salbutamol may show symptoms of local irritation. Adverse drug reactions were identified from data obtained in clinical trials and pharmacovigilance during post approval use of the drug.
The most frequent side effects reported in clinical trials were headache, throat irritation, cough, dry mouth, gastro-intestinal motility disorders (including constipation, diarrhoea and vomiting), nausea, and dizziness.
Immune system disorders: Anaphylactic reaction, Hypersensitivity.
Metabolism and nutrition disorders: Hypokalaemia.
Psychiatric disorders: Nervousness, Mental disorder.
Nervous system disorders: Headache, Tremor, Dizziness.
Eye disorders: Accommodation disorder, Corneal oedema, Glaucoma, Increased intraocular pressure, Mydriasis, Vision blurred, Eye pain, Conjunctival hyperaemia, Halo vision.
Cardiac disorders: Palpitations, Tachycardia, Arrhythmia, Atrial fibrillation, Supraventricular tachycardia, Myocardial ischaemia.
Respiratory, thoracic and mediastinal disorders: Cough, Dysphonia, Dry throat, Bronchospasm, Bronchospasm paradoxical, Laryngospasm, Pharyngeal oedema.
Gastrointestinal disorders: Dry mouth, Nausea, Throat irritation, Diarrhoea, Vomiting, Constipation, Gastrointestinal motility disorder, Oedema mouth, Stomatitis.
Skin and subcutaneous tissue disorders: Skin reactions such as rash, pruritus, urticaria; Angioedema; Hyperhidrosis.
Musculoskeletal and connective tissue disorders: Muscle spasms, Muscular weakness, Myalgia.
Renal and urinary disorders: Urinary retention.
General disorders and administration site conditions: Asthenia.
Investigations: Decreased diastolic blood pressure, Increased systolic blood pressure.